Which statement regarding bone-specific ALP is true?

The statement regarding bone-specific alkaline phosphatase (ALP) that is true is that the bone isoenzyme can be measured immunochemically. This method allows for the specific detection and quantification of the bone isoenzyme due to its distinct structure compared to other isoenzymes of ALP present in the liver or other tissues.

Bone-specific ALP reflects osteoblastic activity and can provide valuable information about bone metabolism. In clinical practice, immunochemical assays that target the bone isoenzyme help differentiate the levels of ALP that are specifically related to bone turnover from those that may originate from the liver or other sources. This specificity is particularly useful in conditions where bone formation is of interest, such as monitoring treatment for metabolic bone diseases.

While all the other statements relate to the clinical implications of bone ALP, they do not accurately represent the primary characteristics or uses of this enzyme. For example, bone ALP levels typically increase during bone formation, not resorption; therefore, associating it with bone resorption would not be correct. Additionally, while bone ALP can provide insights related to conditions affecting bone health, its direct role in diagnosing osteoporosis is limited, as osteoporosis diagnosis relies on multiple factors, including bone mineral density measurements. Lastly, while there are