Which statement accurately describes GH deficiency?

The statement that GH deficiency usually involves all adenohypophyseal hormones is accurate because growth hormone (GH) is secreted by the anterior pituitary gland, also known as the adenohypophysis. In cases of isolated GH deficiency, other pituitary hormones may not be affected, but when GH deficiency is part of a broader condition, it can indicate pituitary dysfunction or failure, which could also affect the secretion of other adenohypophyseal hormones such as adrenocorticotropic hormone (ACTH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH). This interconnectedness highlights the importance of considering the overall function of the pituitary gland when diagnosing GH deficiency.

Other statements have limitations: a random serum GH level in a child under 6 does not definitively rule out GH deficiency, as GH levels can be variable and may require stimulation testing for a conclusive diagnosis. The administration of glucagon actually stimulates GH release rather than suppressing it, as it is one of the agents that can induce GH secretion. Finally, GH levels do demonstrate significant diurnal variation, typically peaking during sleep and fluctuating throughout the day, contrary to the claim