Which statement about multiple endocrine neoplasia (MEN) is true?

The statement regarding multiple endocrine neoplasia (MEN) that is true is that it is associated with hyperplasia or neoplasia of at least two endocrine organs. MEN is a genetic condition characterized by the development of tumors in multiple endocrine glands. The classification of MEN includes several types, such as MEN 1 and MEN 2, each associated with specific endocrine tumors affecting different glands. This condition leads to hyperplastic (enlarged but benign) or neoplastic (tumor formation, which can be benign or malignant) changes in these glands.

The other options do not accurately describe MEN. For example, while insulinomas can occur in some patients with MEN, they are not always present when the pituitary gland is involved. This variability is typical in MEN syndromes, which can manifest in different forms across affected individuals. Additionally, MEN is inherited in an autosomal dominant pattern, not autosomal recessive. Lastly, the elevation of plasma hormone levels from affected organs varies and may not always reach a 10-fold increase, depending on the specific tumor type and stage of disease.