Which of the following statements about aminotransferases (AST and ALT) is true?

The statement that both AST (aspartate aminotransferase) and ALT (alanine aminotransferase) transfer an amino group to α-ketoglutarate is accurate. Aminotransferases are enzymes that facilitate the transfer of an amino group from an amino acid to an α-keto acid, generating a corresponding α-keto acid and glutamate in the process. Specifically, AST catalyzes the transfer of an amino group from aspartate to α-ketoglutarate, producing oxaloacetate and glutamate, while ALT catalyzes the transfer of an amino group from alanine to α-ketoglutarate, resulting in pyruvate and glutamate. This reaction is fundamental in amino acid metabolism and is essential for maintaining the balance of amino acids and the production of energy in the body.

Other statements are not accurate in the context of AST and ALT functionalities or characteristics. The fact that isoenzymes of AST and ALT are found in humans contradicts the first statement. Isoenzymes are different forms of enzymes that catalyze the same reaction and can vary in their properties; therefore, their presence is notable in humans. The second statement about requiring NADP+ as a coenzyme is incorrect since