Which lipoprotein is primarily responsible for transporting endogenous triglycerides?

The primary lipoprotein responsible for transporting endogenous triglycerides is very low-density lipoprotein (VLDL). VLDL is produced by the liver and carries a significant amount of triglycerides that are synthesized from excess carbohydrates and proteins. Once secreted into the bloodstream, VLDL delivers these triglycerides to various tissues in the body, where they can be utilized for energy or stored for future use.

In contrast, other lipoproteins play different roles in lipid transportation. Low-density lipoprotein (LDL) primarily transports cholesterol, particularly from the liver to peripheral tissues, rather than triglycerides. High-density lipoprotein (HDL) is involved in reverse cholesterol transport, bringing cholesterol from tissues back to the liver for excretion or recycling. Chylomicrons, although important for lipid transport, are primarily involved in delivering exogenous triglycerides (from dietary sources) rather than endogenous triglycerides produced by the body.