Which lipoprotein fraction is associated with the pre-β zone during ultracentrifugation?

The pre-β lipoprotein zone during ultracentrifugation is primarily associated with very low-density lipoprotein (VLDL). During this process, lipoproteins are separated based on their density, allowing for the identification of different fractions. VLDL is characterized by being less dense than low-density lipoprotein (LDL) and high-density lipoprotein (HDL), which positions it in the pre-β zone before it transitions to other types of lipoproteins that are denser.

VLDL is primarily responsible for the transport of triglycerides from the liver to peripheral tissues, and its component lipid composition leads it to occupy this specific fraction when subjected to ultracentrifugation. The identification of lipoproteins in these zones is crucial for understanding lipid metabolism and its implications in various health conditions, including cardiovascular disease.