Which enzyme is often elevated in both necrotic jaundice and obstructive jaundice?

The enzyme that is often elevated in both necrotic jaundice and obstructive jaundice is gamma-glutamyl transferase (GGT). GGT is a key enzyme in the metabolism of glutathione and is primarily found in the liver, kidneys, pancreas, and bile ducts.

In cases of obstructive jaundice, which occurs due to a blockage in the bile ducts (such as from gallstones or tumors), GGT levels typically rise significantly because the enzyme is released into the bloodstream when the biliary tree is compromised. Similarly, in necrotic jaundice, which is associated with damage to liver cells (for example, due to hepatitis or liver ulcers), GGT can also increase as the hepatic cells release this enzyme into circulation as they undergo necrosis.

Both conditions result in elevated levels of GGT, making it a useful biomarker for distinguishing between various types of liver and biliary diseases. Its elevation signifies not only liver dysfunction but also indicates an issue with bile flow, further confirming its relevance in both forms of jaundice.