Which apoprotein is inversely correlated with the risk of coronary heart disease?

Apoprotein A-I plays a crucial role in lipid metabolism, particularly in relation to high-density lipoprotein (HDL) cholesterol. It is a primary protein component of HDL, which is often referred to as "good" cholesterol due to its protective role in cardiovascular health. An increased level of Apoprotein A-I is associated with higher levels of HDL, which helps to remove cholesterol from arteries and transport it to the liver for excretion. This function is inversely correlated with the risk of coronary heart disease; higher levels of Apoprotein A-I indicate a lower risk, as it reflects a favorable lipid profile that promotes cardiovascular health.

In contrast, other apoproteins mentioned have different relationships with coronary heart disease. For instance, Apoprotein B100 is primarily found in low-density lipoprotein (LDL) and is associated with an increased risk of heart disease due to its involvement in cholesterol transport and plaque formation in arteries. Apoprotein C-II is involved in the metabolism of triglycerides, but its exact relationship with coronary heart disease can vary depending on other factors. Apoprotein E4 is linked with the metabolism of lipoproteins and is associated with an increased risk of Alzheimer's disease, making its relevance to coronary heart disease