What would be expected in a patient with Dubin-Johnson syndrome?

In Dubin-Johnson syndrome, a patient typically presents with elevated conjugated bilirubin levels. This genetic disorder affects the liver's ability to transport conjugated bilirubin, leading to its buildup in the bloodstream. Patients generally exhibit mild jaundice due to the accumulation of this bilirubin, which is water-soluble and can be detected in serum.

Unlike other conditions that may raise unconjugated bilirubin, Dubin-Johnson syndrome specifically results in increased conjugated bilirubin because the liver is able to conjugate bilirubin but fails to secrete it into the bile. This is characterized by a darkly pigmented liver upon pathological examination, which is a distinctive feature of the syndrome.

Normal bilirubin levels would not be seen in this condition since the hallmark is the elevation of conjugated bilirubin. Similarly, one would not expect reduced urine bilirubin excretion; instead, there may actually be some urinary bilirubin present due to the increased levels of conjugated bilirubin in the bloodstream.