What type of detector is typically used in high-performance liquid chromatography with electrochemical detection (HPLC-ECD)?

In high-performance liquid chromatography with electrochemical detection (HPLC-ECD), the glassy carbon electrode is commonly used due to its favorable electrochemical properties. Glassy carbon electrodes have a large surface area, high conductivity, and excellent stability in various chemical environments, making them ideal for detecting a wide range of analytes.

This type of electrode enables sensitive and selective measurements because it can facilitate the oxidation or reduction of soluble species, allowing for the detection of low concentrations of compounds. The material's chemical inertness also helps in minimizing background currents, which contributes to improved detection limits and overall performance of the HPLC system.

While other electrodes have their specific applications, they may not provide the same combination of sensitivity, stability, and wide applicability that glassy carbon electrodes offer in the context of HPLC-ECD.