What should be done next after finding that total protein levels are abnormal while other biochemistry test results are normal?

After encountering abnormal total protein levels while other biochemistry test results are normal, repeating the total protein test is a prudent next step. This is important for several reasons.

Total protein levels can be influenced by a variety of factors, including hydration status, dietary intake, and even the timing of the sample collection. Errors in sample handling, such as hemolysis or improper storage, can also affect the results. By repeating the total protein test, you ensure that the initial abnormal reading was not due to an artifact or a transient factor.

If the repeat yield confirms the abnormality, this could indicate an underlying pathological condition that requires further investigation. In clinical practice, verification of abnormal results is a standard step to improve diagnostic accuracy before proceeding with additional tests. This helps in directing further evaluations appropriately, such as performing protein electrophoresis, which can provide more detailed information about the protein composition of the serum if needed later on.