What caused the false elevation in ammonia levels in the provided sampling situation with a heparin lock?

Study for the Harr Clinical Chemistry Test. Use flashcards and multiple choice questions for each topic covered. Each question includes hints and explanations to help you understand. Prepare effectively for success!

The false elevation in ammonia levels, in this case, is most likely due to stasis of blood in the heparin lock. When blood is allowed to remain stagnant in a vascular access device, such as a heparin lock, it can lead to various biochemical changes, which may include the breakdown of cells and increased release of ammonia into the surrounding plasma.

Ammonia is produced primarily through the metabolism of amino acids and the deamination of nucleotides. When blood is stagnant, it creates an environment conducive to cellular degradation and metabolic processes that can artificially elevate ammonia concentrations. This is especially critical in clinical settings where accurate ammonia measurements are essential for diagnosing and managing conditions like hepatic encephalopathy or metabolic disorders.

Other choices do not adequately explain the reason for the observed elevation. Physiological variation can occur in ammonia levels but is not typically the primary reason for such a significant artifact. Contamination from an ammonia source would imply an external factor that is usually not the case unless there is improper handling, which is not a given in this situation. Similarly, collecting from the wrong patient would imply direct contamination from an entirely different biological sample, rather than an artifact stemming from the blood collection methodology itself. Thus, stasis in the heparin

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