What can elevated ALP with increased GGT suggest?

Elevated alkaline phosphatase (ALP) levels along with increased gamma-glutamyl transferase (GGT) levels are most commonly indicative of a hepatic source. ALP is an enzyme found in various tissues throughout the body, including the liver and bone. When ALP is elevated, it can signal issues related to either bone or liver pathology. However, the presence of increased GGT helps to differentiate between these sources.

GGT is an enzyme that is particularly sensitive to liver disease and is often elevated in conjunction with ALP when the underlying cause is hepatic. The combination of high ALP and elevated GGT typically points to cholestasis or other liver-associated conditions, rather than bone disorders. In situations involving bone pathology, GGT levels usually do not increase substantially, so the presence of elevated GGT supports the likelihood of a liver issue. Hence, when both ALP and GGT are increased, it suggests a condition affecting the liver rather than other sources.